Abstract P342: Life’s Simple 7 Among Statin Users and Non-Users at High Cardiovascular Risk. The Polish Norwegian Study-PONS

Abstract

Introduction: Cardiovascular risk reduction requires the pharmacological treatment of hyperlipidemia to be accompanied by the adoption of healthy behaviors. Whether statin users do so, is not clear and both, false reassurance and healthy adherer-phenomena have been theorized. Our objectives were: 1) to compare AHA Life’s Simple 7 (LS7) prevalence in statin users vs. non- users among statin candidates at high cardiovascular risk and 2) to assess LS7 among potential statin users candidates for Ethyl eicosapentaenoic acid (EPA) treatment. Methods: We used cross-sectional, baseline data of 12754 participants, age 45 to 64 years in a community-based cohort study (PONS). Data were collected through structured questionnaires and fasting blood samples. LS7 were defined based on AHA criteria. Statin use was recorded by trained nurses. We defined as high risk those with clinical ASCVD or diabetes, and those with LDL higher than 190 mg/dL. Statin users potential candidates for EPA therapy were defined based on the REDUCE-IT trial entry criteria. Results: There were 2722 (21.3%) individuals at high risk, of which 791 (29.1%) were using statins. Compared to non-users, statin users were older, mean age (SD) 59 (4) vs. 57 (5), more men (37.4% vs. 32.7%), had lower TC, 185.3 (43) vs. 224.7 (48), lower LDL, 105.6 mg/dL (39) vs. 141.5 (46) , more obesity, 46.1% vs.39.6%, less controlled blood pressure 5.5 % vs. 5.6%, less optimal plasma glucose, 48.3 % vs. 53.2% and more AHA poor diet, 40.1% vs. 32.7% (all p-val. less than 0.05). More statin users than non-users (90.6% vs 73.6%) had poor cardiovascular health, with an age- and sex-adjusted OR (95% CI) of 3.2 (2.4-4.2). The prevalence of potential statin users EPA candidates in the full, community-based sample was low (73 individuals, 0.6%); these individuals had poor glucose control (42.5%), high prevalence of obesity (64.4%) and poor AHA diet (32.4%). Conclusion: Statin users had a worse LS7 profile than non-users, with most unhealthy behaviors being poor diet and obesity. In the context of efficacious pharmacological agents, behavioral cardiovascular health remains an unfulfilled target.