Abstract P342: Demographic and Risk Factor Profiling of Patients With Abnormally High and Low Ankle Brachial Index in a Nationally Representative Cohort

Abstract

Background: Ankle Brachial Index (ABI) is widely used for diagnosis and prognostication in patients with peripheral vascular disease. Both abnormally high and low ABIs have been associated with increased risk of cardiovascular events. Although multiple demographic and other risk factors have been linked to high and low ABI, differences and distribution in a national cohort has not been described previously. Methods: We did a descriptive cross sectional analysis on the cohort of continuous National Health and Nutrition Examination Survey (NHANES) between the years 1999-2006 (n=31124). We included only those with baseline ABI data on both extremities (n= 6819). Chi-square test and ANOVA were used to measure the differences for categorical and continuous variables. Results: We found 6577 people with normal ABI (0.9 to 1.4), 214 with abnormally low ABI (<0.9) and 28 with abnormally high ABI (≥ 1.4). The demographic and risk factor distribution among all the 3 groups has been shown in Table 1 . Conclusion: Patients with both high and low ABI have increased prevalence of risk factors compared to cohort with normal ABI. The prevalence and distribution of these differences could be helpful for targeted health interventions. Table 1 Variable ABI < 0.9(214) ABI ≥ 1.4(28) Normal ABI(6577) p value Age 71.9±10.3 61.4±12.5 59.1±12.7 <0.0001 Race White Black Other 57.9 21.9 20.1 67.9 3.5 28.6 54.1 17.6 28.3 0.01 Gender -Male 47.7 42.9 48.5 0.81 BMI * 27.9±5.6 31.1±8.6 28.3±5.5 <0.001 Triglyceride 166±102 137±56 162±157 <0.001 Cholesterol 208±45 198±35 210±41 <0.001 LDL # - cholesterol 124±41 134±26 125±35 <0.001 HDL † -Cholesterol 51±16 49±12 53±16 0.09 Smoking 20 10.7 19.9 0.008 Homocysteine 12±4.6 9±2.8 9.5±4.8 <0.001 Creatinine 1.1±0.5 0.84±0.3 0.88±0.4 <0.001 Waist Circumference 101±14 107±18 99±14 <0.001 Hypertension 69.6 39.3 39.8 0.01 Myocardial Infarction 14 7.14 3.07 <0.001 Coronary Artery Disease 11.2 3.6 3.2 <0.0001 Angina 6.5 7.1 2.7 0.001 Diabetes Mellitus 25.2 17.9 11.7 <0.0001 Stroke 6.5 7.2 1.9 <0.0001 * Body Mass Index, #Low Density Lipoprotein, † High Density Lipoprotein