Abstract P3110: Sex Differences In Ventricular Tachycardia Ablation In-hospital Outcomes: An Analysis From The National Inpatient Sample Database

Abstract

Background: There are limited data available comparing outcomes of ventricular tachycardia (VT) ablation in men versus women. Objectives: For patients undergoing ablation for VT, we sought to determine if sex-based differences in outcomes and procedural complications exist. Methods: We queried the National Inpatient Sample (NIS) database between 2016 and 2018 to identify patients aged ≥18 years hospitalized with a primary diagnosis of VT who underwent ablation. Patients with other cardiac arrhythmias or who had an implantable defibrillator/pacemaker placement were excluded. Multivariable logistic regression analysis was performed to assess independent predictors of any procedural complication. Results: Out of 7,200 identified admissions for VT involving VT ablation, 1,280 (18%) were women and 5920 (82%) were men. Men were older (mean age 64.8 vs 57.4 years in women, P<0.01). Comorbidities as prior myocardial infarction (MI), prior CABG, Chronic kidney disease (CKD), COPD, prior cardiac pacemaker, chronic heart failure (CHF) and peripheral vascular disease (PVD) were all significantly more prevalent in men.The primary outcome of in-hospital mortality occurred in 3% of both men and women. Interestingly, the length of stay was longer in men (6.53±4.2 vs 5.26±2.5 days, p<0.01). The incidence of acute MI, acute ischemic stroke, bleeding, need of blood transfusion, tamponade, complete heart block, pulmonary complications, vascular complications similar between men and women, however acute kidney injury occurred more in men (21% vs. 10%, p< 0.001). The overall complication rate was significantly higher in men (28.8% vs 20.7 %, P= 0.0084). The presence of CKD, as well as CHF were independent predictors of any procedural complication (OR 1.27, 95% CI 1.19-1.36, P <0.01) and (OR 1.08, 95% CI 1.03-1.14, P=0.001). Conclusion: Men had higher rates of in hospital complications following VT ablation which might be related to higher rates of comorbidities. There was no difference in in-hospital mortality between men and women. Women represented only 17.8% of VT ablation admissions. Further studies are needed to distinguish the sex-based differences in VT ablation referrals and to compare long term outcomes post ablation.