Abstract P3-08-72: Poor prognosis in elderly patients with breast cancer resulted from under-treatment in patients with triple negative breast cancer and mortality from other than breast cancer

Abstract

Abstract Background: Breast cancer is the leading cause of malignant disease in Korean women nest to thyroid cancer. Age is one of the significant risk factor and Korean population is aging rapidly, almost 1.5 times older than a half century ago, from 52.4 years in 1960 to 78.5years at 2005. While it is uncertain the proportional incidence is also increasing, absolute number of elderly patients is increasing and unmet clinical needs and unanswered questions are remained in the clinical practice for elderly patients. The aim of this study is to outline breast cancer in elderly patients and examine survivals by clinicopathologic factors such as age, stage and disease subtype. Material and Methods: Patients who were diagnosed and completed their primary treatment for breast cancer from 2000 to 2013 were included. Clinicopathologic data was collected with retrospective data review and survival data and risk factors, if the survival was statistically significant, were obtained. Results: 1103 patients with invasive breast cancer were included. Mean age was 52.71±11.478(22-89). Subjects were divided into three group, <40 (n=147, 35.9±3.704), 40-60 (n=680,49±5.131), >60(n=276,68.6±5.62). Patients over 60 had statistically worse overall survival(p=0.011) and distant disease free survival(p=0.012) with Kaplan-Meier method with log rank test and hazard ratio(HR) of elderly was 2.206 with 1.046-4.658 96% Confidence Interval(CI). For the worse prognosis of elderly, triple negative breast cancer who got less than standard systemic treatment (HR=4.836, 95% CI, 1.514-15.452) and mortality from other than breast(HR=2.395, 95% CI,1.106-5.188) cancer were significantly correlated with higher mortality in elderly patients. Conclusion: Elderly patients with breast cancer experience significant worse survival when they got less than standard systemic treatment or second primary disease other than breast cancer in their follow up period. Citation Format: Gilseong Moon, Ji wool Ko, Hany Noh, In-Jeong Cho, Jong-in Lee, Airi Han. Poor prognosis in elderly patients with breast cancer resulted from under-treatment in patients with triple negative breast cancer and mortality from other than breast cancer [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P3-08-72.