Abstract P308: Pilot Study: 24 Hour and Daytime Blood Pressure Lowering Effect of Melatonin in Younger and Older Non-hypertensive Adults

Abstract

The study objective was to study the effect of melatonin on blood pressure (BP) in both younger and older normotensive and prehypertensive individuals. Preliminary data available at the time of abstract submission are presented for 12 participants (10 ≤ 50 years old; two ≥ 60). free of known hypertension or diabetes. All subjects had office and 24 hour ambulatory BP measured before and after dosing of 9 mg controlled release melatonin for six weeks. Subjects are described in Table 1 . Full data analysis for all 30 pilot subjects, including 12 older and 10 control subjects, will be available for the presentation. Table 2 shows results comparing baseline and follow-up BP. Mean 24 hour SBP/DBP, as well as ambulatory daytime SBP/DBP, were significantly lower following melatonin administration. In conclusion, these findings suggest possible future utility of melatonin for lowering BP in both younger and older non-hypertensive individuals.