Abstract P3028: Animal In Vivo: The Proof Of Flow Choking And Bulging Of The Downstream Region Of The Stenosis Artery Due To Air Embolism

Abstract

Background: Evidences are escalating on the asymptomatic cardiovascular diseases and disorders associated with air embolism due to the flow choking (biofluid/Sanal flow choking) [PMID: 32837737 & PMID: 34326352]. Flow choking occurs anywhere in the circulatory system at a critical systolic to diastolic blood pressure ratio (BPR) <https://doi.org/10.1161/res.129.suppl_1.P422>. Flow choking leads to the shock-wave generation followed by pressure overshoots if the downstream region of the choked artery is having divergence/bifurcation regions. Methods: Animal in vivo study has been carried out on 6 th December 2021, IST: 2:00-4:00 PM (the FIRST in the World) for establishing the phenomenon of flow choking in a stenosis artery at a critical BPR due to air embolism. The high pressure air is injected into the upstream region of the stenosis using a syringe (see Fig.1(a)). Stenosis is created using a knot. Syringe infusion pump is used for altering the flow rate and upstream pressure. The multiple animal in vivo studies were carried out on 31 st December 2021 . It aims for demonstrating the phenomenon of flow choking followed by bulging and/or tearing of the downstream region of the stenosis artery of a small animal. Results: Figure 1(b) shows the animal in vivo (with the approval of the ethics committee) for the live demonstration of flow choking and bulging in a stenosis artery due to air embolism. Herein, we established the proof of the concept of flow choking due to air embolism in the stenosis-artery at a critical BPR (SBP/DBP) causing the risk of asymptomatic cardiovascular diseases and disorders. Conclusions: We concluded that at a critical BPR, the flow choking occurs in any artery. The shock wave generation due to flow choking leads to cardiovascular risk. Frequent flow choking creates memory effects (stroke history) in the downstream region due to the enhanced wall stiffness as a result of pressure-overshoot due to multiple shock waves. We further concluded that the critical BPR is a risk factor of flow choking causing asymptomatic cardiovascular disease, if the downstream region of the choked artery is having divergent shape.