Abstract P285: Sociodemographic and Metabolic Risk Characteristics Associated with Metabolic Weight Categories in the Women's Health Initiative

Abstract

Introduction: To identify sociodemographic and metabolic correlates of weight categories in postmenopausal women. Hypothesis: We assessed the hypothesis that postmenopausal women with metabolically unhealthy normal weight (MUHNW), metabolically healthy overweight/obese (MHO), and metabolically unhealthy overweight/obese (MUHO) were more likely to have adverse risk factors as compared to those with metabolically healthy normal weight (MHNW). Methods: The Women’s Health Initiative (WHI) enrolled 161,808 postmenopausal women ages 50-79. We included those free of cardiovascular disease (CVD) and with CVD risk factors and biomarkers (n=19,412). Normal weight was defined as a body-mass index (BMI) ≥18.5 and <25 kg/m 2 and waist circumference (WC) <88 cm and overweight/obesity as a BMI > 25 kg/m 2 or WC > 88 cm. Metabolically healthy was based on <2 and metabolically unhealthy > 2 traits: triglycerides > 150 mg/dl, systolic blood pressure (BP) > 130 mmHg or diastolic BP > 85 mmHg or antihypertensives or diuretics, fasting glucose > 100 mg/dl or diabetes medication, and HDL-cholesterol <50 mg/dl. Multinomial logistic regression with generalized link logit function provided the odds ratio (ORs) of MHNW, MUHNW, MHO and MUHO. Results: The table shows the ORs of risk factors and biomarkers. Among the 19,412 participants, 2,369 (12.2%) had prevalent diabetes and a mean age of 63.3 ± 0.05 (SEM). Advanced age was associated with a greater odds of MUHNW and a lower odds of MHO as compared to the MHNW after adjusting for covariates. African-Americans were associated with a decreased likelihood of MUHNW and MUHO, while Hispanics were associated with a decreased likelihood of MHO and MUHO as compared to MHNW. Low-income had a greater odds of MUHNW, yet high-income had a lower odds of MHO or MUHO. Total cholesterol, insulin and C-reactive protein were associated with a greater odds of MUHNW, MUHO or MHO. Conclusions: Advanced age, ethnicity, income and biomarkers are important indicators of metabolic weight categories among postmenopausal women.