Abstract P274: Pregnancy-induced-hypertension and the Risk of Postpartum Hypertension Among Gestational Diabetes Women

Abstract

Background: Previous studies in the general people indicated that pregnancy-induced hypertension (PIH) increased the risk of subsequent hypertension after delivery. Some studies found that women with gestational diabetes mellitus (GDM) had an increased risk of PIH. However, very few studies have assessed the association between PIH and the risk of postpartum hypertension among GDM women. Aims: To evaluate the association between PIH and the risk of postpartum hypertension among GDM women. Methods: We performed a retrospective cohort study in 1261 GDM mother at 1-5 years after delivery using the baseline data from Tianjin Gestational Diabetes Mellitus Prevention Program. Cox regression models were applied to assess the single and joint associations of having a history of PIH, maternal pre-pregnancy BMI (normal weight, overweight and obesity), and weight change from pre-pregnancy to postpartum with the risk of subsequent hypertension among the GDM women. Results: GDM people with a history of PIH, high pre-pregnancy BMI, and weight gain more than 7 kg from pre-pregnancy to postpartum were associated with an increased risk of postpartum hypertension. Joint effects analysis revealed that the positive association between a history of PIH in the index pregnancy and the risk of postpartum hypertension was consistent in GDM women with different levels of pre-pregnancy BMI or weight gain from pre-pregnancy to postpartum. Conclusion: A history of PIH increases the risk of subsequent hypertension in postpartum 1-5 years among GDM women. We suggest highlight the pregnancy guide in different stages and pay more attention on this group of people.