Abstract P273: Longitudinal Association Between Body Weight Change and 6-year Change of Blood Pressure in Japanese Men

Abstract

Objective: Overweight is associated with increases in the risks of hypertension and cardiovascular disease. However, long-term and especially repeated measures analysis about relationship between body weight (BW) change and blood pressure (BP) change is only a little. We investigate the longitudinal relationship between BW change and years-long change of BP in a prospective cohort study. Participants: A total of 2546 male employees aged 25-53 years without use of antihypertensive drug in a metal products factory in Japan. Measurements: The BP was annually measured once in the right arm after 5 min of rest in a seated position, by well-trained nurses using a standard mercury sphygmomanometer from 2003 (baseline) to 2009. Physical examinations and information on lifestyle and use of medicine were annually measured or confirmed during the same period. The associations between difference of BW from 2003 to 2008 and 6-years change of systolic and diastolic BP from 2003 to 2009 were analyzed with generalized estimating equation models. Covariates in full adjusted model were age, body mass index, and smoking and drinking status in baseline. Results: Mean ± standard deviation (SD) of age, height, and BW in 2003 was 39.3 ± 8.0 years, 170.6 ± 6.0 cm, and 68.2 ± 9.9 kg, respectively. Mean ± SD of BW in 2008 was 68.8 ± 10.2 kg. Mean ± SD of systolic and diastolic BP in 2003 were 119.7 ± 14.6 and 74.3 ± 11.3 mmHg, respectively. Systolic and diastolic BP in 2009 were 120.5 ± 15.1 and 76.4 ± 10.9 mmHg, respectively. In full adjusted model, 1 kg increase of BW in 5 years was significantly associated with 0.17 mmHg higher systolic BP ( P = 0.024) and 0.113 mmHg diastolic BP ( P = 0.012) in 6 years. Conclusions: Beyond relevant covariates, increasing BW significantly elevated both systolic and diastolic BP.