Abstract P271: Relationship of Resting Heart Rate and Subclinical Arteriosclerosis Markers in Apparently Normal Participants From China

Abstract

Objective: To evaluate the relationship between resting heart rate and arterial stiffness in natural and apparently normal population of She minority from Fujian province in China. Method: 6 natural village 511 participants were enrolled into our study using cluster sampling method in 2009. Eventually 325 subjects with full data were analyzed. All subjects carried on detection of carotid femoral pulse wave velocity(CF-PWV), carotid radial pulse wave velocity (CR-PWV), cardio ankle vascular index(CAVI), ankle brachial index(ABI), carotid intima media thickness(CIMT) by Doppler ultrasound and blood test (fasting plasma glucose[FPG], blood lipids, blood uric acid(UA), high sensitive C reactive protein(hs-CRP). Resting heart rate(RHR) was the mean of three values measured by VS-1000 vascular detection equipment and ultrasound equipment. Results: In different quartiles of RHR, that were RHR1≤61beats/min, RHR2:62-69beats/min, RHR3:70-77beats/min, RHR4≥78beats/min, systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol to high density lipoprotein cholesterol ratio (TC/HDL-C), HDL-C, CF-PWV and CR-PWV were significantly different between RHR groups (p<0.05); SBP, DBP, TC/HDL-C, CF-PWV and CR-PWV in RHR4 group were significantly higher than RHR1 group, and HDL-C was lower than RHR1 group (all p<0.05). However, there were no statistical significance of CAVI, ABI and CIMT in different RHR groups (p>0.05). Logistic regression analysis indicated in the model without adjustment, the RHR4 was associated with higher CF-PWV(CF-PWV>9m/s) with odds ratios (ORs) was 3.074 (95% confidence interval was 1.555-6.075, p<0.05) compared with RHR1; After adjustment of age and gender, the OR of RHR4 was 4.542 (95% confidence interval was 2.078-9.928, p<0.05); And after further adjustment of SBP, DBP, plasma lipids, FPG and hs-CRP, the OR of RHR4 was 5.336 (95% confidence interval was 1.512-18.831, p<0.05). Conclusion: In natural population of She minority of Fujian province in China, high resting heart rate was followed by a high level of blood pressure, plasma lipids and arterial stiffness. Furthermore, a higher rest heart rate was independently associated with arterial stiffness.