Abstract P230: Adherence to the MIND Diet is Associated with a Favorable Profile of Subclinical Cardiac Remodeling in the Framingham Offspring Cohort

Abstract

Introduction: The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet is based on the central components of the Mediterranean and DASH diets and emphasizes foods that may provide a neuro-cognitive benefit. To date, no study has investigated adherence to the MIND diet and indices of cardiac remodeling. We hypothesized that adherence to the MIND diet may have a favorable impact on indices of cardiac remodeling. Methods: Multivariable linear regression related the MIND diet score to echocardiographic indices of cardiac remodeling in 2569 Framingham Offspring cohort participants (mean age, 67 years; 55% women). The MIND diet score contains 15 components, each with a maximum score of 1 (max score =15). We averaged MIND diet scores across 2-4 exam cycles. Primary and secondary echocardiographic measures are in Table 1 . Simple models (model 1) were adjusted for age, sex, and total energy intake, and additional models (model 2) were further adjusted for BMI, smoking, total/high-density lipoprotein cholesterol (TC-HDL) ratio, heart rate, diabetes, systolic blood pressure, and use of anti-hypertensive medication. Results: Participants had a mean (±SD) cumulative MIND diet score of 6.9 (± 1.7). The cumulative MIND diet score was significantly associated with favorable measures of E/e’, GLS, GCS, and MAPSE in model 1 ( Table 1 ). Associations between the MIND diet score and echocardiographic measures were attenuated and became non-significant in model 2 ( Table 1 ). A higher MIND diet score was associated with lower levels of several clinical risk factors including BMI (β±SE (p value): -0.01±0.002 (<.0001)), TC-HDL ratio (-0.05±0.01 (0.0002)), heart rate (-0.83±0.12 (<.0001)), with lower odds of diabetes (OR [95% CI]: 0.88 [0.82, 0.94]), and use of anti-hypertensive medication (0.94 [0.90, 0.99]). Conclusions: Favorable associations between cumulative adherence to the MIND diet and echocardiographic indices are likely mediated by the favorable impact of adherence to the MIND diet on clinical risk factors.