Abstract
Background: Potato consumption is highly prevalent all around the world. Previous studies have reported a positive association of potato intake with hypertension and diabetes due to high glycemic load. However, data are scarce on potato consumption and risk of coronary artery disease (CAD). Hypothesis: We hypothesized that potato consumption is positively associated with risk of CAD. Method: We prospectively studied 148,671 participants from Million Veteran Program(MVP). We used a Willett food frequency questionnaire to assess consumption of baked, boiled, and mashed potatoes. The incidence of CAD was assessed through electronic health record. We used Cox Proportional hazard model to compute the hazard ratio and 95% confidence interval (95% CI) for CAD events across categories of potato intake. Results: The average age of men was 64 years ( SD = 12) and 90 % were men. A total of 6,309 new cases of CAD occurred during mean follow up of 2.7 ± 1.4 y. Median potato consumption was 1 cup/week. The crude incidence of CAD from lowest to highest categories of potato consumption was 14.1, 15.0, 15.2, 16.1, and 18.9 per 1000 person-years, respectively. Hazard ratios ( 95% CIs) of CAD were 1.00 ( reference), 1.01 (0.92-1.11), 1.02 ( 0.93-1.11), 1.04 (0.95 - 1.15), and 1.21 (1.07-1.36) for potato intake of <1 cup/month, 1-3 cups/month, 1 cup/week, 2-4 cups/week, and 5+ cups/week respectively, adjusting for age, gender, race, body mass index (BMI), alcohol consumption, exercise, smoking, overall diet quality, and education (P for linear trend = 0.01). The observed relation of potato consumption with CAD was not modified by age, BMI, gender, and ethnicity. In a sensitivity analysis, exclusion of CAD events occurred during the first year did not alter the findings. Conclusion: Frequent (5+ cups/week) but not infrequent potato consumption was associated with a higher risk of CAD among MVP participants.
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