Abstract P2064: Changes in Inflammatory Markers Monitored Across Time After Bariatric Surgery in Severely Obese Patients

Abstract

Adipose tissue is a higly active endocrine tissue and produce adipokines, peptides produced by adipose tissue and exerting autocrine, paracrine and endocrine function. Objective: to analyze changes (Δ) in serum levels of several adipokines and inflammatory markers in morbidly obese patients (MO) after bariatric surgery (BS) at several follow-up time points. Methods: Fifty-two MO (81% women, 40% hypertensives, age 43.9±8.9 yr, BMI 42.2±5.4 Kg/m 2 , waist circumference 131.6±12.1 cm) were evaluated prospectively before and 1,3,6 and 12 months (m) after BS, with assessment of anthropometric data and serum concentrations of several adipokines and inflammatory markers. BS technique: laparoscopic gastric by-pass (28 of 52) and sleeve gastrectomy (24 of 52). Results: at 12m body weight (-35.7±10.2 Kg) and waist circumference (-27.2±9.4 cm) decreased (p<0.001). Two inflammatory markers, leptin and hsCRP, decreased at 1,3,6 and 12m (p<0,005 for all). Adiponectin and angiopoetin-2 increased from month 3 on. (Table). These Δ were statistically significant when examined by an ANOVA with repeated measures, excepte for adiponectin (p=0.065). After adjusting for age, sex, and BS technique, the BS technique was statistically significant only for ΔhsCRP (p=0.035). Pearson correlations were explored. There were no statistically significant correlation between Δ body weight or Δ waist circumference with changes of any of these markers at any follow-up time point. Conclusions: there is a decrease in inflammatory markers 1 m after BS in MO patients with progressive decrease throughout 12 m. These changes are independent of the BS technique and of Δ in body weight and waist circumference.