Abstract P203: Dietary Magnesium, C-reactive Protein and Interleukin-6: The Strong Heart Family Study

Abstract

Background: Both experimental animal and human observational studies have suggested that magnesium (Mg) deficiency influences systemic inflammation. Whether this association is modified by genes associated with Mg metabolism and transport is unknown. Objective: To examine associations of reported Mg intake, and the interaction of reported Mg intake with a single nucleotide polymorphisms (SNP) related to Mg metabolism and transport, on serum markers of inflammation (i.e., C-reactive protein (CRP) and interleukin 6 (IL-6)). Methods: This cross-sectional study included 1,924 participants from the Strong Heart Family Study—a study of risk factors for cardiovascular diseases among American Indians (AIs) from 12 communities in the United States. Intake of Mg from foods and dietary supplements was ascertained using a 119-item Block food frequency questionnaire. Serum hsCRP and IL-6 were measured from blood collected after a 12-hour fast, and candidate SNP (rs3740393) was genotyped using MetaboChip. Generalized estimating equations, with clusters defined by family membership, were used to examine associations of Mg intake, and the interaction of rs3740393 with estimated dietary Mg, on CRP and IL-6. Results: FFQ-estimated Mg intake was not associated with CRP or IL-6. We observed no interaction of reported Mg intake with rs3740393 on CRP (p-interaction=0.70). However, we observed an interaction (p-interaction=0.018) of reported Mg intake with rs3740393 on IL-6. (Table). Conclusion: Reported Mg intake is inversely associated with serum IL-6 among carriers of the C allele at rs3740393. Future research is necessary to replicate this finding, and to examine other Mg-related genes that may influence associations of Mg intake or sufficiency with inflammation.