Abstract P2-14-27: Impact of surgery on survival in patients with stage IV breast cancer: A population-based study from the SEER database

Abstract

Abstract Surgical treatment for stage IV breast cancer remains controversial. Therefore, we aimed to further explore the impact of surgery on survival in patients with stage IV breast cancer using the Surveillance, Epidemiology, and End Results (SEER) database. We selected 3,822 patients diagnosed with stage IV breast cancer from 2010 to 2012 in the SEER database who were divided into surgery and non-surgery groups. We assessed the breast cancer-specific survival (BCSS) and overall survival (OS) of the two groups using Kaplan-Meier plots and Cox proportional hazard regression models. In addition, we performed stratification analyses of breast subtype, tumor size and status of distant metastasis to identify the effects of these factors on surgical outcomes. The median survival times were 30 and 24 months in the surgery and non-surgery groups, respectively. The Kaplan-Meier curves showed that the surgery group survived longer than the non-surgery group. The hazard ratios (HR) of the surgery group were 0.504 for BCSS and 0.507 for OS (P<0.001). Furthermore, patients in the surgery group still experienced significantly better survival than those in the non-surgery group when stratified according to breast subtype, tumor size and status of distant metastasis. Surgical treatment appears to be associated with improved survival in patients with stage IV breast cancer, independently of breast subtype, tumor size and status of distant metastasis. Citation Format: Song C-G, Lin Y-X, Zhang J, Zeng Q, Chen M-Y, Chen L-L, Wang X-X, Chen Q-X. Impact of surgery on survival in patients with stage IV breast cancer: A population-based study from the SEER database [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P2-14-27.