Abstract P2-03-01: An Investigation of Factors Influencing Real-Time Tissue Elastography Score

Abstract

Abstract [Purpose] At 32nd SABCS, we reported that Real-time Tissue Elastography (EG) score was useful in the examinations of mass-forming breast lesions. The results suggested that a possibility of being invasive carcinoma may practically be ruled out when a mass-forming breast lesion scored 1 or 2 on EG. Because the stiffness is relatively visualized in EG, it is possible that the score is influenced by the state of the patient's breast. We examined the factors influencing EG scores in mass-forming breast lesions. [Subject and Method] EG scores of 502 patients with breast lesions (150 malignant, 352 benign) whose tissues were diagnosed histopathologically from October 2007 to December 2009 were studied. The hardness was scored on a scale 1 to 5 on Tsukuba elasticity scoring system. [Results] In the 502 cases of mass-forming breast lesions there was a significantly higher score for non-invasive carcinoma and invasive carcinoma than for benign lesions (< 0.0001). No difference in score was observed in a comparison of the location (lateral quadrants, medial quadrants) of the mass-forming lesion. There were significantly lower scores (< 0.0001) in 10 mm in diameter or smaller when comparing three groups of tumor mass diameters: 10 mm in diameter or smaller, 11-20 mm, and 21-30 mm. When the breast density of two groups were examined, “almost entirely fat or scattered fibroglandular tissue” group and “heterogeneously dense or extremely dense” group, there were significantly low scores in the “heterogeneously dense or extremely dense” group (< 0.0001). When the two groups divided by median area of the mammography were examined, there were significantly low scores in the larger breast group (< 0.0001). Although in the total cases examined, all cases were benign in score 1, 6% were malignant in score 2 (5 cases non-invasive carcinoma, 4 cases invasive carcinoma). When 3 cases in which pathology results of the surgical specimen were obtained were examined among the 4 cases of invasive carcinoma, widespread intraductal spread was observed in the surrounding invasive carcinoma. [Conclusion] Through this investigation we ascertained that EG scores are influenced by lesion size and the state of the patient's breast. In addition, care must be taken given the possibility of low scores in invasive carcinoma with widespread intraductal spread. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P2-03-01.