Abstract P197: Vitamin D, Paratohormone and Cardiovascular Risk: The Good, the Bad and the Ugly

Abstract

25OH Vitamin D (VitD) insufficiency and increased cardiovascular risk (CVR) association is still debated. The VitD dependendent paratohormone (PTH), is considered as the possible actuator of VitD effects on CVR. In an overall population observational study, we assessed the role of PTH in predicting CVR. We recruited 412 persons during the World Hypertension Day, in the area of Salerno, Southern Italy. Through means of dedicated questionnaires, blood pressure measurements and a blood draught, we collected dietary habits, anamnestic, clinical and metabolic data. CVR was calculated according to the Framingham CVR charts. The overall population mean age±SD was 49.9±20 yrs, and female sex was slightly prevalent (53.2%). VitD deficiency (<20 uMol/ml) was most frequent (65.4%). In this population VitD and CVR did not correlate. VitD and PTH inversely correlated (r=-0.236, p<0.001) as expected. PTH was in direct linear regression with CVR (F=14,982, p<0.0001). Elevated PTH (>=56 mg/dl) levels identify a population with higher CVR (11.9±6.2 vs 9.2±7.1, p<0.01) and larger prevalence of cardiovascular events (10,2 vs 4.1, p<0,04). Since PTH increases with age and kidney function, we selected a 41-60 years old population (N=150). Also in this homogenous group, people with elevated PTH present a larger cardiovascular risk (8.4±10.5 vs 4.1±4.8, p<0,01) due to higher systolic blood pressure (137.2±20.4 vs 130.1±16.0, p<0.05). In conclusion, VitD deficiency causes PTH elevation that in the overall population increases the CVR. Our data let hypothesize that VitD supplementation may represent a major presidium to reduce PTH level and consequently CVR.