Abstract P187: Elevated Resting Heart Rate is Associated With Dyslipidemia in Chinese Rural Population: The Henan Rural Cohort Study

Abstract

Aim: The aim of this study was to explore the association between resting heart rate (RHR) and dyslipidemia in Chinese rural population. Simultaneously, we examined whether this association was mediated by some degree of fasting plasma glucose (FPG). Methods: A total of 38727 participants aged 18-79 years were derived from the Henan Rural Cohort Study during 2015-2017 in China. Restricted cubic splines and logistic regression were used to estimate the OR s and 95% CI s. Mediation analysis using bootstrap was performed to examine the contribution of FPG to RHR-related dyslipidemia. Results: The results showed that RHR were associated with the risk of dyslipidemia, and the corresponding adjusted OR s (95% CI s) for each quartiles were 1.00, 1.12(1.05-1.20), 1.22(1.15-1.30), 1.45(1.36-1.54), respectively. In continuous analysis, each 1SD increment in RHR was significantly associated with a 15% increased risk of dyslipidemia. The restricted cubic splines showed that the risk of dyslipidemia increased gradually with continuous RHR. In mediation analysis, the percentage of excess relative risk mediated for FPG was 24.63%. Conclusion: Elevated RHR was significantly associated with the risk of dyslipidemia in Chinese rural population. In addition, RHR -related dyslipidemia was mediated by some degree of FPG. However, the potential clinical application remains to be determined. Figure OR (solid lines) and 95% CI (dashed lines) for the risk of dyslipidemia along with the changes of resting heart rate from restricted cubic splines. Adjusted for age, gender, education level, marital status, smoking, drinking, physical activity, family history of dyslipidemia and body mass index.