Abstract P180: Comparison of the Framingham Risk Score With Coronary Artery Disease Burden in Hispanics

Abstract

Background: The Framingham risk score (FRS) predicts the 10-year risk of having a myocardial infarction (MI). However, the accuracy of the FRS in hispanics has not been throughly evaluated. We compared coronary artery disease (CAD) severity with FRS by ethnic groups in patients undergoing cardiac catheterization. Methods: We performed a cross-sectional analysis of 178 consecutive patients who were referred for elective coronary angiography at Jackson Memorial Hospital in Miami. We measured the components of the FRS and evaluated ethnicity by self-report. We evaluated CAD severity based on the coronary angiography results. We defined severe CAD if the patients had >= 70% luminal obstruction in a vessel or >=50% in the left main coronary artery. We also evalauted severity as a continuos score of the number of vessels with narrowings>=50%. We calculated the median and interquartile range (IQR) of FRS and correlated with the CAD severity and the p-value for trend as well as analysis of variance to determine if FRS differed by ethnicity adjusted for confounders. Results: We identified 110 patients who identified as Hispanic and 68 patients identified as non-hispanics. At baseline, Hispanics had a mean FRS of 10.0±3.8 and non-Hispanics had a mean FRS of 10.3±5.9 (p=0.70). In Hispanics the median FRS for patients with >= 70% stenosis was 10% (IQR 8.5-13) compared to <70% stenosis 9 % (IQR 5-13). In non-Hispanics with >= 70% stenosis the median FRS was 12.5% (IQR 10-16) compared to those with <70% stenosis 8 % (IQR 4-11). The same differences were seen when using >=50% stenosis (table). Conclusions: The FRS does not correlate with coronary artery disease severity in Hispanics but does correlate with CAD severity in non-Hispanics. Median and IQR of FRS by degree of stenosis and ethnicity Severity of stenosis * Hispanics Non-Hispanics >=70% 10 (8.5-13) 12.5 (10-16) >=60% 9 (5-13) 8 (4-11) >=50% 10 (9-13) 12 (9-15) <50% 9 (6-13) 8 (5-14) * p<0.01 for comparisons between severe CAD and non-severe CAD by ethnicity