Abstract P174: Free Triiodothyronine Level Correlates with Statin Responsiveness in Acute Myocardial Infarction

Abstract

Background: Although thyroid hormone (TH) has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesized that TH plays an important role in statin responsiveness in AMI patients. Methods: Consecutive 1091 hospitalized AMI patients in Fuwai hospital were enrolled. The study population was divided into three groups based on the intensity of statin treatment: low (n=221), moderate (n=712) and high (n=158). Lipid levels were measured after statin therapy lasting for 10-14 days. We explored the association between TH, lipid levels and achievement of low density lipoprotein cholesterol (LDL-C) lowering goals in patients with acute myocardial infarction (AMI) on statin therapy. Results: By general linear analysis, a significant linear trend between FT3 and LDL-C level (linear coefficient=-0.082, P =0.001) and FT3 and total cholesterol (TC) level (linear coefficient=-0.105, P =0.031) was observed in the moderate-intensity statin group. A more apparent linear trend was detected in the high-intensity statin group (for LDL-C: linear coefficient=-0.113, P =0.005; for TC: linear coefficient=-0.172, P=0.029, respectively). However, no significant correlation was observed in the low-intensity statin group. Compared with the low-T3 group (defined as FT3<1.79 pg/ml), the OR (95% CI) for attaining a LDL-C<3.0mmol/L was found to be 2.217 (1.001-4.839) in the higher FT3 group (>2.95 pg/ml).The OR for attaining the more intensive goal (LDL-C<1.8mmol/L) (95% CI) was 2.836 (1.014-5.182). Conclusions: Variation in FT3 levels is related to the lipid-lowering responsiveness of statins in AMI patients.