Abstract

Introduction: Hypertension affects over a billion people worldwide and contributes to millions of cardiovascular deaths annually. Furthermore, COVID-19 was a global health crisis that led to numerous deaths. Due to a paucity of data, we aimed to study the effect of COVID-19 on patients with hypertensive emergency and to identify positive predictors that led to increased healthcare utilization. Methods: A retrospective analysis was completed utilizing the National Inpatient Sample (2020). Patients were identified based on ICD-10 codes corresponding to those with Hypertensive Emergency and COVID-19 vs. patients with only Hypertensive Emergency. Primary outcomes were all-cause mortality, length of stay (LOS) and total hospital charge (TOTHC). Secondary outcomes of race, insurance, and post-procedural complications were analyzed using multivariate analysis. Results: 1,685,745 patients had COVID-19, of which 284,350 had hypertensive emergency. After propensity score matching, patients with Hypertensive Emergency and COVID-19 had increased mortality (OR 2.21, 95% CI [2.05- 2.40], p=0.00), LOS (+2.38, 95% CI [1.70- 3.05], p=0.00) and TOTHC (+69558.30, 95% CI [$51,437.27- $87,679.34], p=0.00). It was shown that either CVA, ESRD, or AKI increased mortality, TOTHC, and LOS in patients with Hypertensive Emergency and COVID-19. Conclusion: In the wake of the COVID-19 pandemic, this study demonstrates the impact of hypertensive emergency as a significant factor increasing mortality, LOS and TOTHC. Moving forward, efforts should be made to improve out of hospital treatment and to reduce the number of admissions for hypertensive emergencies in these conditions.

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