Abstract P167: Hypertension And Diseases Associated With Gut Microbiome Alterations: Insights From The National Inpatient Sample (nis) From 2020

Abstract

Introduction: Hypertension (HTN) is a common condition at the focus of global health efforts. While great strides have been made towards the treatment and diagnosis of this condition, its relationship with the gut microbiome requires further investigation. We sought to assess the impact of HTN on various conditions associated with alterations of the gut microbiome. Methods: A retrospective analysis was completed utilizing the NIS. Patients were identified based on ICD-10 codes corresponding to those with essential hypertension (HTN) alone vs those with HTN and a gut microbiome disease (GMD). These included ulcerative colitis (UC), gastroparesis, clostridium difficile (C. diff), irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO). Primary outcomes were mortality, (mean length of stay (LOS) and total hospital charge (TOTCHG). Results: Of 8,667,791 patients with HTN, 39,280 had UC, 81,085 had gastroparesis, 9,285 had C. diff, 110,320 had IBS, and 12,295 had SIBO. Patients with HTN and GMD had an OR of 0.65 (CI 0.63-0.67, p = 0.00). Native Americans with concurrent HTN and GMD had an OR of 1.56 (CI 1.33-1.83, p = 0.00). LOS was increased in patients with HTN and concurrent gastroparesis and C. diff (Table 1). Having Medicare, Medicaid, being admitted with UC, gastroparesis or C. diff and being of asian or hispanic heritage were significantly associated with higher costs. Conclusion: HTN in the presence of a disease associated with alteration of the gut microbiome does not demonstrate a negative effect on mortality. It does, however, demonstrate increased mortality in Native American populations as well as increased LOS in gastroparesis and C. diff.