Abstract P152: Clinical Utility Of Visceral Adipose Tissue Volume In Identification Of Middle Age Adults With Type 2 Diabetes

Abstract

Background: Higher visceral adipose tissue (VAT) volume is associated with greater risk for the development of type 2 diabetes (T2D). Although VAT volume and prevalence of T2D vary by sex and race, differences in VAT volumes that are associated with the identification of individuals with prevalent T2D across these groups has not been fully examined. Objective: Our goal was to determine VAT volume cut points that maximize true positive, true negative, and optimal identification of individuals with T2D according to sex and race. Methods: Data were examined from the Coronary Artery Risk Development in Young Adults (CARDIA) study, a multi-center longitudinal study of the development of cardiovascular risk in black and white men and women ages 18-30 years at baseline. In 2010-2011, the Year 25 exam was performed (43-55 years). VAT (cm 3 ) was quantified by computed tomography based on two 5 mm contiguous slices at the level of the 4 th -5 th lumbar vertebra (n=3,161). T2D was defined based on the presence of fasting plasma glucose ≥126 mg/dL, 2-hour post load blood glucose ≥200 mg/dL, HbA1c ≥6.5% and/or diabetes medication use. Receiver operating characteristic (ROC) curve analysis was used to identify VAT cut points associated with identification of T2D. Results: Prevalence of T2D at the year 25 exam ranged from 8.8% in white women to 17.7% in black men; mean (SD) VAT volume ranged from 113.5 (79.9) cm 3 in white women to 170.2 (80.2) in white men. White men exhibited the highest cut points of VAT volume needed to identify cases of T2D (26-35% higher) and black women exhibited the lowest cut points (4-36% lower) for true positive, true negative, and optimal identification of T2D compared to other race and sex groups (Table 1). Conclusions: Although the utility of VAT volume to identify individuals with T2D is modest [[Unable to Display Character: –]] likely a result of other unaccounted metabolic risk factors [[Unable to Display Character: –]] these cross-sectional findings display race and sex differences in the VAT volume cut points associated with prevalent T2D.