Abstract P145: Sodium Potassium Ratio And Blood Pressure Levels In Adults

Abstract

Background/Objectives: To assess the association between Sodium-potassium ratio and blood pressure levels in adults. Subjects/Methods: In 396 randomly distributed residences, we carried out cross-sectional measurements on participants adults from Vitória, a southeastern city in Brazil. Anthropometry, blood pressure, and fasting blood were measured on the same day by trained personnel at the University research clinic. The blood pressure mean was calculated from 2 measurements after 5 minutes of rest. The Na/K ratio was calculated from the 24-hour urine collection carried out after participants received the instructions (the first collection in a plastic cup (0.7 L), then transferring the content to the storage bottle (2 L), and keeping it in the refrigerator). We considered valid 24-hour urine collections for those with collection times between 23 and 25 hours, no report of urine loss, and volume >500 mL. A questionnaire was applied for sociodemographic variables. We performed ANOVA to compare variances across the Na/K tertile means and blood pressure and crude and adjusted linear regressions to assess the associations. Statistical significance was established in p < 0.05. Results: From 272 remaining participants with valid 24-hour urine, Na, K, and blood pressure data, 54% were girls, with a mean age of 44 ± 14 years old balance between age groups and no difference (p > 0.05) between genders. A significant increase in Systolic 1.53 (CI 95%: 0.26 -2.80) and Diastolic 1.27 (CI 95%: 0.54 -2.00) blood pressure was related to the Na/K ratio increase, even after adjusting for sex, BMI, and skin color. Conclusions: The sodium-potassium ratio is associated with blood pressure levels increment. These findings suggest the importance of dietary interventions to promote a balanced Na/K ratio, which may contribute to preventing and managing high blood pressure levels in adult populations.