Abstract
P1425 Citation: Atherosclerosis Supplement 2009, Vol. 10, Issue 2 ANTI-INFLAMMATORY AND ANTI-OXIDATIVE EFFECTS OF VITAMIN E-COATED MEMBRANE DIALYZER IN CHRONIC HEMODIALYSIS PATIENTS D Kirmizis, A Papagianni, A-M Belechri, G Efstratiadis, E Alexopoulos, D Memmos University Department of Nephrology, Hippokration General Hospital, Thessaloniki Aim: To investigate the effects of the use of vitamin E-coated membrane dialyzer (VEM) on markers of oxidative stress and inflammation in chronic hemodialysis (HD) patients. Patients-Methods: 35 patients (19 males, mean age 55±16 years) were dialyzed for 6 mts using a hollow fiber VEM dialyzer (VEM group). 25 ageand sex-matched HD patients (12 males, mean age 6±213 years) were dialyzed for the same period using al lowor medium-flux dialyzer as before their inclusion in the study (controls). Serum TAS was measured by RANDOX assay, TBARS by TBARS assay, CRP by nephelometry, IL-6, sICAM-1, sVCAM-1 and sEselectin and plasma oxLDL by ELISA. Results: In the VEM group, a significant decrease in CRP (p=0.02) and IL-6 (p=0.02) was observed at 3 mts compared with baseline. At 6 mts a significant decrease was noticed in CRP (p=0.004), IL6 (p=0.004) and sICAM-1 levels (p=0.04), as well as a tendency for decrease in sVCAM-1 and sE-selectin (p=0.6 & p=0.2, respectively), a significant reduction in TBARS (p=0.04) and oxLDL (p<0.001) and an increase in TAS (p=0.005). In contrast, compared with baseline, no significant changes were observed at 6 mts in any of the study parameters in the control group. Conclusions: In HD patients, a 6-mts use of VEM dialyzers exerted primarily anti-inflammatory effects which were followed by anti-oxidative effects. The observed decrease in the markers of oxidative stress is probably, at least in part, secondary to the improvement of endothelial function and the decrease in LDL oxidation. Funding: Any funding sources of commercial nature for the work being presented are disclosed.
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