Abstract P135: Bone Mineral Density is Associated With Vascular Endothelial Function and Arterial Stiffness in Apparently Normal Population From China

Abstract

Objective: To evaluate the relation of vascular parameters with bone mineral density (BMD) in the apparently normal population. Background: Vascular parameters including brachial arterial flow-mediated vasodilatation (FMD), brachial ankle pulse wave velocity (ba-PWV) and ankle brachial index (ABI), are reported associated with bone health. However, prior investigations have been limited to highly selected samples. Methods: We studied 165 individuals without a history of cardiovascular disease in the Chinese Arteriosclerosis Series Evaluation-She Minority Study (CASE-SMS) cohort (mean age 46.94±11.23 years, 59.4% women). BMD was quantified by dual-energy X-ray absorptiometry (DXA). Results: Age-adjusted analysis showed there was no difference in FMD, ba-PWV, ABI, lumbar vertebra BMD and left hip BMD between male, premenopausal female and postmenopausal female (all p>0.05). Multivariable linear analysis showed that FMD (B=0.005, p=0.016) and ba-PWV (B=-0.009, p=0.014) were both associated with lumbar vertebra BMD independently of each other. Multivariable logistic analysis showed FMD and ba-PWV were both related to low BMD in total (FMD OR 0.860, 95% CI 0.802 to 0.922, p<0.001; ba-PWV OR 1.494, 95% CI 1.275 to 1.751, p<0.001), male (FMD OR 0.861, 95% CI 0.757 to 0.979, p=0.022; ba-PWV OR 1.523, 95% CI 1.190 to 1.951, p=0.001), premenopausal female (FMD OR 0.842, 95% CI 0.734 to 0.966, p=0.014; ba-PWV OR 1.421, 95% CI 1.063 to 1.899, p=0.018) and postmenopausal female population (FMD OR 0.825, 95% CI 0.715 to 0.952, p=0.008; ba-PWV OR 1.740, 95% CI 1.187 to 2.551, p=0.004). In all the analyses, ABI was not associated with BMD (all p>0.05). Conclusion: There was no difference in FMD, ba-PWV, ABI, lumbar vertebra BMD and left hip BMD between male, premenopausal female and postmenopausal female after adjusting for age. FMD and ba-PWV were independently associated with lumbar vertebra BMD and low BMD. However, ABI was not associated with BMD.