Abstract P134: Does Co-morbid Obesity Change Hospitalization Outcomes In Patients With Hypertensive Crisis?

Abstract

Introduction: The prevalence of hypertension and obesity has been soaring, emerging as major global health problems. Similarly, optimal management of hypertension in obese individuals has been a perpetual struggle due to barriers to accurate diagnosis, monitoring, and treatment, primarily due to complex body habitus and intricate underlying pathological facets. Methods: The National Inpatient Sample database (NIS) 2020 was employed to identify hospitalizations with Hypertensive crisis which were further dichotomized based on Co-morbid obesity using ICD-10 codes. The primary outcome was inpatient mortality. The secondary outcomes were inpatient complications, mean length of stay (LOS), and mean total hospital charge (THC). Multivariate linear and logistic regression analyses were utilized to adjust for possible confounders. Results: There were 132,995 patients with primary diagnosis of hypertensive crisis, of which 31,400 (23.6%) were obese. Analysis showed similar adjusted odds of inpatient mortality (Adjusted Odds Ratio [aOR]: 0.85, [95% CI: 0.43-1.67], p=0.57). Obese patients were more likely to develop acute coronary syndrome (ACS) during hospitalization (2.4% vs 2%, P=0.036), and acute kidney injury (AKI) (27.1% vs 23.7%, p<0.001) than non-obese patients with hypertensive crisis (Figure 1) Conclusion: Hospitalizations for hypertensive crisis among obese individuals had similar inpatient mortality compared to those with normal BMI. However, obese patients had higher odds for ACS and AKI. Further clinical studies should be directed toward this patient population to mitigate the associated risk and improve outcomes.