Abstract P1159: Association Of Membrane Ferritin Transporter And Transferrin Receptor Plasma Levels With Coronary Atherosclerosis

Abstract

Objective: Given the potential role of iron in inflammation and atherosclerosis, we investigated the correlation between the plasma levels of membrane ferritin transporter (FPN) and soluble transferrin receptor (sTFR) with the severity of coronary artery stenosis (CAS). Methods: Clinical data of 85 patients admitted to our institution between August 2022 and December 2022 with suspected coronary artery disease (CAD) was utilized. Patients were stratified according to their coronary angiography results: CAD group (n=50) and control group (n=50). Patients with CAD were further divided depending on their use of statin: statin taking group (PSU, n=15) and non-statin taking group (NSU, n=35). The coronary Gensini score was used to assess the severity of CAS. Spearman’s regression analysis was used to correlate plasma FPN and sTFR concentrations with the severity of CAS. Results: Plasma sTFR [2,216.88 (1,922.42, 2479.01) ng/mL vs. 1,928.96 (1490.50, 2289.23) ng/mL] concentration was higher in patients with CAD, while HDL cholesterol [0.94 (0.84, 1.17) mmol/L vs. 1.14 (0.95, 1.38) mmol/L] and plasma FPN [0.71 (0.42, 2.71) ng/mL vs. 2.90 (1.32, 4.40) ng/mL] concentration was lower when compared to patients without CAD. The coronary Gensini score was positively correlated with plasma sTFR concentration (R s =0.24, p =0.045) and negatively correlated with plasma FPN concentration (R s =-0.28, p =0.021). Plasma FPN level [1.50 (0.52, 4.77) ng/mL VS 0.51 (0.28, 2.46) ng/mL, P=0.007] in PSU patients was higher than the NSU group. Levels of total cholesterol [3.71±0.28mmol/L VS 4.67±0.15mmol/L, P=0.002] and low-density lipoprotein [2.24±0.25mmol/L VS 2.96±0.10mmol/L, P=0.002] were significantly lower in the PSU group. Regression analysis indicates that low plasma FPN concentration is an independent risk factor for the development of CAD ( p =0.038). Conclusion: Our results suggest that sTFR and FPN concentrations are positively and negatively correlated respectively with the severity of CAS. Furthermore, regression analysis indicates that low plasma FPN concentration is an independent risk factor for the development of CAD. While our data provides some reference for evaluating the incidence and severity of CAD, future research is needed to verify our results.