Abstract P106: Blood Pressure Regulation After Lisinopril Therapy in Persons With Diabetes

Abstract

Objectives: The aim of this study was to assess the regulation of blood pressure after three months of antihypertensive therapy in persons with type 2 diabetes mellitus. Design and Methods: The study sample consisted of 398 persons with arterial hypertension and type 2 diabetes, aged 63.9±9.6 years. Hypertension was treated with 10 mg lisinopril (98 patients), 20 mg lisinopril (140 patients), or with fixed combination of 20 mg lisinopril and 12.5 mg hydrochlorothiazide (160 patients). Blood pressure (BP) was measured by an oscillometric device at the beginning of the study, one month later, and after three months of therapy. A ‘well-regulated’ blood pressure was defined as systolic BP less than 140 mmHg, and/or diastolic BP less than 90 mmHg one month and three months after the initiation of therapy. Logistic regression was used to predict good regulation of SBP and DBP after three months of therapy in relation to age, gender, smoking habits, body mass index, and regulation of blood pressure one month after the beginning of therapy. Results: At the beginning of the study, the average SBP was 159.4±12.7 mmHg, average DBP was 96.3±8.5 mmHg. After one month, average SBP was 140.5±18.6 mmHg, average DBP was 87.8±8.1 mmHg. At that stage, SPB was well-regulated in 127 persons (31.9% of the sample), whereas DBP was well-regulated in 189 persons (47.5% of the sample). After three months of therapy, average SBP was 132.4±9.0 mmHg, and average DBP was 81.6±6.0 mmHg. At that stage, SPB was well-regulated in 286 persons (71.9% of the sample), whereas DBP was well-regulated in 339 persons (85.2% of the sample). The only significant predictor for the good regulation of SBP after three months of therapy was good regulation of SBP one month after the beginning of therapy (Odds Ratio=2.44; 95% Confidence Interval =1.44-4.13). The only significant predictor for the good regulation of DBP after three months was good regulation of DBP one month after the beginning of therapy (OR=8.08; 95% CI =3.71-17.63). These prediction models were independent of age, gender, body mass index, smoking habits, and lisinopril treatment. Conclusion: The regulation of BP after three months of antihypertensive therapy with lisinopril depends on the good regulation of BP one month after the initiation of therapy.