Abstract P1048: Lattice-Boltzmann Method Achieves Feasible Hemodynamic Analysis In Carotid Atherosclerosis With Low Computational Cost

Abstract

Introduction: Atherosclerosis is a common cardiovascular pathophysiology that can lead to plaque-related complications, including stroke and myocardial infarction. Non-invasive hemodynamic analysis can provide valuable insights into the plaque's rupture vulnerability and growth progression. Computational fluid dynamics is widely studied to understand hemodynamic pathophysiology further; however, traditional computational fluid dynamics methods often require daily-based analysis time to visualize hemodynamic parameters. This study investigated the feasibility of using the lattice Boltzmann method (LBM) for hemodynamic analysis of atherosclerosis lesions. Methods: From ten carotid artery stenosis patients, 20 carotid artery models were generated and analyzed using LBM. Hemodynamic parameters, including time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), and relative residence time (RRT), were compared between the stenotic lesion and contralateral control sides. The patient-specific boundary conditions were applied. Their cardiac cycle was subdivided into three periods: systolic acceleration, systolic deceleration, and diastolic, and analyzed to investigate their relationship with the hemodynamic parameters. Results: LBM effectively captured the hemodynamic parameters associated with carotid atherosclerosis with an hourly-based computational cost (2.765 [2.435-3.233] hours). The analysis visualized high TAWSS and low RRT distribution at stenotic areas during the systolic deceleration period and low TAWSS and high RRT distribution at the post-stenotic distal lesion during the diastolic period. These findings were reproducible among the ten patients. Conclusion: LBM-based hemodynamic analysis has the potential to serve as a non-invasive diagnostic tool that can help understand atherosclerosis pathophysiology with low computational cost.