Abstract P094: Prevalence Of Polycystic Ovary Syndrome In Youth With Hypertension Disorders

Abstract

Introduction: While Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among adolescent females, it continues to be underdiagnosed and understudied. In particular, it is unknown whether youth with HTN may have a greater undiagnosed burden of PCOS compared to the general adolescent population. Patients with PCOS are at an increased risk for reproductive morbidities, hormone-dependent cancer, and metabolic and cardiovascular diseases. Furthermore, the relationships between metabolic syndrome (MBS) or obesity and PCOS in patients with HTN have not been fully investigated. Objectives: To estimate the prevalence of PCOS in adolescent females with HTN and investigate whether MBS and obesity increase this risk. Methods: This is an ongoing prospective cross-sectional study that has enrolled 12 of 40 participants to date. Inclusion criteria are females 10-18 years with HTN disorders of any cause and menarche for ≥2 years. Exclusion criteria are CAH, ovarian or pituitary cancer, Cushing syndrome, pregnancy, and a diagnosis of PCOS prior to HTN diagnosis. Data are collected via EHR abstraction and administered questionnaires, and include demographics, past medical, menstrual, and fertility histories, blood pressure, and physical characteristics including height, weight, and waist circumference. Our power and sample size calculations, made a priori, are based on estimating the difference in our population’s hypothesized PCOS prevalence (p1=0.25) with that of the general adolescent female population (p0=0.1) using the one-sample z-test of proportions. We will also use multivariable generalized linear models to estimate the risk of PCOS due to MBS or obesity. Results: The median systolic and diastolic blood pressures are 122.7 mmHg [113.8, 128.0] and 72.5 mmHg [68.8, 76.6]. The median waist circumference is 80.7 cm [76.5, 95.6]. The prevalence of PCOS is 17% (2/12), while 8% (1/12) have MBS and 58% (7/12) have obesity. Discussion: We are continuing to enroll new participants to reach our target enrollment of 40. Our results have the potential to educate clinicians to consider screening for PCOS in adolescent females who present with HTN to allow for prevention of the comorbidities associated with PCOS and to guide HTN treatment.