Abstract P074: Heterogeneity In Proportional Mortality Due To Atherosclerosis By Age Amongst Asian Americans

Abstract

Background: Asian American subgroups (AAS) differ amongst one another in terms of proportion of mortality (PM) due to atherosclerosis disease (ASD). However, differences in PM based on early onset (35-64 years) and older age (≥65 years) ASD deaths within each subgroup have not been well studied. Methods: US resident death records were examined from 2017 mortality data (National Center for Health Statistics). Race/ethnicity and underlying ASD cause (ICD-10 code of ischemic heart disease I20-I25, ischemic stroke I69, atherosclerosis I70, respectively) were tabulated for Asian-American subgroups and major US race/ethnicities (listed in Table). Age and sex standardized PM percentage was calculated overall for each ethnicity and separately for early and older age deaths within each ethnic group. The age by ethnicity interaction was tested using general linear models. Results: Over all ages, Filipinos and Asian Indians had the highest ASD PM while Vietnamese and Japanese had the lowest ASD PM, with other groups being intermediate. Compared with NHW, ASD PM was high in both age groups for Asian Indians and Filipino, while age difference PM in these ethnic groups was no different when compared to NHW – suggesting early and persistently high ASD. In contrast, Amerindians, Hispanics, Koreans and Chinese when compared to NHW had a low early age ASD PM, increasing significantly at older ages, suggesting the mortality burden is mostly at older ages. Conclusion: AAS are heterogeneous in terms of the overall burden of percent ASD mortality and the age at which it predominates. Asian Indians and Filipinos had the highest PM burden due to ASD over all ages, premature and older. On the other hand, premature ASD mortality burden was lowest in Koreans and Chinese amongst the AAS with a disproportionate increase in death in the elderly population. AAS subgroups need different strategies for prevention, with Asian Indians and Filipinos being targeted earlier in their life course.