Abstract P064: The Activity Of Antioxidant Enzymes In Patients With Arterial Hypertension, Depending On The Environmental Comfort Of Life

Abstract

Oxidative stress is known as one of the mechanisms for the development of endothelial dysfunction. Prooxidants and antioxidants are usually produced in humans, and there is a balance between production and disposal. When the balance between oxidizing agents and antioxidants is disturbed, oxidative stress occurs. Purpose: assessment of the activity of antioxidant enzymes in patients with arterial hypertension, depending on the environmental comfort of life. Materials and methods: Fifty-six patients from a random stratified sample of city residents by age and gender were examined. To determine the relationship between hypertension and environmental comfort, all subjects, depending on the ecological comfort of life, were divided into groups that were formed based on the “Map of the ecological comfort of life in the city of Rostov-on-Don”, developed by V.V. Privalenko. The age of the subjects ranged from 25 to 64 years, with an average value of 46.79 ± 0.63 years: group Ia - 14 healthy subjects and group IIa - 12 patients with hypertension living in ecologically clean areas; group Ib - 16 healthy subjects and group IIb - 14 patients with hypertension living in ecologically unfavorable regions. First-line protective antioxidants: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) were evaluated in patients' blood plasma. Statistical data processing is carried out using the program Statistica 6.0. Results: The maximum activity of GPX (347.04 ± 11.39) was recorded in healthy people living in areas with an ecologically unfavorable environment. CAT levels were also higher in healthy people living in areas with an unfavorable environment (p<0.05). Minimal GPX activity was found in patients with arterial hypertension (265.85 ± 12.46) who also live in ecologically unfavorable areas (p<0.05). Differences in GPX activity in healthy people and hypertensive patients living in ecologically polluted areas were statistically significant (p<0.05). Results: The activity of antioxidant enzymes in healthy people living in environmentally disadvantaged areas is increasing. With the development of arterial hypertension, we observed an insufficient antioxidant response, which reflects the depletion of the antioxidant system's capabilities.