Abstract P060: Sedentary Behavior is Directly Associated With Higher Prevalence of Chronic Kidney Disease in Older Adults: The Framingham Heart Study

Abstract

Introduction: Self-reported physical inactivity and sitting time have been associated with a greater prevalence of chronic kidney disease (CKD) in middle-aged populations. However, data are limited regarding the association of objectively-assessed physical activity and sedentary behavior with prevalence of CKD among older adults. Hypothesis: We hypothesized that higher physical activity and less sedentary time will individually and conjointly be associated with a lower prevalence of CKD in older adults. Methods: We evaluated 1,318 Framingham Offspring cohort participants (mean age 69.3 years, 53.9% women) with accelerometry-derived physical activity data (wear time ≥ 10 hours/day for at least 4 days) at examination 9 (2011-2014). CKD was defined as an eGFR < 60 ml/min/1.73 2 and/or urine albumin-to-creatinine ratio (UACR) ≥ 25/35 micrograms/mg (men/women) at examination 9. Multivariable logistic regression models were used to relate physical activity and sedentary time with the prevalence of CKD adjusting for covariates (Table). In sensitivity analysis to mitigate reverse causality, we excluded participants with more advanced CKD (eGFR<30 ml/min/1.73 2 ). Results: Men spent more time in moderate to vigorous physical activity (MVPA) (mean 21.7 min/day) and less time in sedentary time (mean, 660.7±76.9 min/day), compared to women (mean MVPA, 15.6 min/day; mean sedentary time, 675.8±70.5 min/day). Overall, 279 participants had prevalent CKD (20.8%; 127 women). Higher sedentary time was associated with a higher prevalence of CKD after adjusting for risk factors and MVPA in sensitivity analysis, the association remained significant. MVPA was inversely associated with CKD prevalence in minimally-adjusted models only. Conclusions: Our cross-sectional observations on a sample of older adults are consistent with the notion that reduction of sedentary time in the elderly may have salutary effects on kidney function. Additional studies of multiethnic cohorts are warranted to confirm our observations.