Abstract P058: Hostility Attitudes & Prevalent or Future Diabetes Among Black Adults: The Jackson Heart Study

Abstract

Background: Hostility and diabetes mellitus (DM) share common determinants such as obesity, tobacco use and physical inactivity. Thus, we investigated their unstudied relationship at baseline and at 10 yrs after among Black adults in the Jackson Heart Study (JHS), a group with high rates of DM. Hypothesis: Hostility and its subdomains (hostile affect, aggressiveness, and cynicism) correlate with DM at baseline or at 10 yrs after. Methods: From the JHS cohort (n=5301), we studied 3,434 Blacks who completed the Cook-Medley Hostility Scale. Hostility was measured in 3 subdomains: hostile affect, cynicism and aggressiveness; higher scores correlated with higher hostility levels. Participants were stratified into quartiles based on the hostility scale. Frequency of DM at baseline or at 10 yrs after was compared amongst quartiles and tested for trend. Using multivariate logistic regression, we studied the cross-sectional relationship between quartiles of levels of hostility and the combined outcome of presence of diabetes at present or at 10 yrs after, adjusting for known confounders of DM. Subanalyses were conducted at each hostility domain level. Results: Our population was 35% men with a mean age of 54.3 (SD 12.6) yrs. Quartiles were associated with age, BMI, smoking, hA1c, caloric intake, hs-CRP, and alcohol intake (all p<0.05). Overall hostility quartiles and its subscales correlated with DM at baseline but only the subdomains of hostile affect and cynicism correlated with DM at 10 yrs. When prevalent or DM at 10 yrs were assessed as a combined risk, individuals in the last quartile of the hostile affect subdomain was associated with a higher DM risk versus first quartile (Table). Similar link was not found in other subdomains. Conclusions: Hostility attitude was associated with DM risk factors and prevalent DM. Only 2/3 of the hostility subdomains correlated with DM at 10 yrs after. Individuals from the last quartile of hostile affect subdomain was related to a higher risk of prevalent or DM at 10 yrs when compared to the first quartile.