Abstract P057: Cardiovascular Diseases and Cancer Incidences Associated With Cardiovascular Risk Profile: Results from MATISS Italian Cohort

Abstract

Background: Individuals with low levels of cardiovascular risk factors experience low incidence of subsequent cardiovascular diseases (CVD). The aims of this study were to assess cancer incidence in people with favorable (low) CVD risk profile and its association with educational level (EL). Methods: The MATISS longitudinal cohort comprised 3609 men and 4146 women aged 20-70 years, free of CVD and cancer at baseline with validated non-fatal and fatal CVD and cancer events during a median 17.7 years of follow-up. People at baseline were classified as ‘low risk’ with total cholesterol <240 mg/dl and blood pressure <140/90 mmHg and BMI <30.0 kg/m 2 and no hypertension treatment and no diabetes and no smoking habit and ‘high risk’ (total cholesterol >=240mg/dl or blood pressure >=140/90 mmHg or BMI >=30.0 kg/m 2 or hypertension treatment, diabetes, smoking). EL was classified as low (LEL=elementary school) and middle-high (MHEL=middle/high school/university). Results: 724 cancer and 571 CVD events occurred; 22.7% of participants were ‘low risk’; 77.3% were ‘high risk; 61.5% had LEL. Cancer and CVD incidences increased with age; age-adjusted cancer and CVD incidence were higher in men compared to women (cancer: 68.92 versus 48.95 x 10,000 person-years; CVD: 64.18 versus 29.5 x 10,000 person-years). Incidences of cancer and CVD were higher in LEL (cancer: 83.22 versus 50.35 x 10,000 person-years in men and 51.67 versus 33.59 x 10,000 person-years in women; CVD: 70.07 versus 64.84 x 10,000 person-years in men and 30.72 versus 17.89 x 10,000 person-years in women). Persons with ‘low risk’ profile experienced less cancers and CVD than persons with ‘high risk (cancer: 37.66 versus 72.3 x 10,000 person-years in men and 39.57 versus 50.07 x 10,000 person-years in women; CVD: 18.49 versus 69.75 per 10,000 person-years in men and 20.34 versus 30.7 x 10,000 person-years in women). In analysis by risk profile and EL considered together for both genders rates of both CVD and cancer were highest in those with less education classified as high risk (cancer: 85.2 versus 56.13 x 10,000 person-years in men and 50.97 versus 35.12 x 10,000 person-years in women; CVD: 74.58 versus 69.06 per 10,000 person-years in men and 30.87 versus 22.69 x 10,000 person-years in women). Conclusions: Increasing educational levels and prevalence of low CVD risk profile in the general population may be effective strategies for population-wide CVD and cancer prevention.