Abstract P046: Baseline Insulin Sensitivity From Oral Glucose Tolerance Test Are Associated With Incident Dyslipidemia: The Ansan-Ansung Community Cohort Study

Abstract

Introduction: Insulin resistance and dyslipidemia are often comorbid. Although possible biochemical explanations exist, there is still too small community based longitudinal data to support the theory directly. Objectives: This study aimed to test the association between the baseline of insulin sensitivity from oral glucose tolerance test (OGTT) and the incidence of dyslipidemia in a community cohort. Secondly, we tested which lipidemia profile is associated with tertiles of Matsuda index. Methods: Participants (n=3899; aged 40-69 years, during visit1 to 7, mean follow-up for 12 years) were recruited from the Ansan-Ansung cohort study, a subset of Korean Genome Epidemiology Study. OGTT were measured at baseline examination. Baseline Matsuda index was calculated by the formula 10 4 /((GLU0xINS0xGLU60xINS60) 0.5 ). We then used tertiles of Matsuda index. The associations of Matsuda index tertiles with the incidence of dyslipidemia and each component of the lipid profile during 12 years were assessed by logistic regression. Age, body mass index, alcohol drinking, cigarette smoking, c reactive protein, education level, and income were adjusted at the final model. Results: Tertile groups were divided: low tertile(<6.25, N=1306, 33.50%), tertile 2 (6.25-10.89, N=1277, 32.75%), and tertile 3(≥10.89, N=1316, 33.75%). Low tertile (referent: tertile2) was associated with greater incident dyslipidemia in total before (OR=1.39, 1.13-1.72) and after adjustment (OR=1.26, 1.02-1.57). Low tertile was associated with greater incident triglycerides≥200mg/dl in total (OR=1.33, 1.10-1.62), women (OR=1.35, 1.01-1.81) and men (OR=1.34, 1.03-1.74) before and adjustment. However low tertile was not associated with other dyslipidemia profiles such as HDL, LDL, and total cholesterol. Conclusions: Low tertile of insulin sensitivity at baseline had increased associations with future incidence of dyslipidemia especially with triglycerides component.