Abstract P028: Increased Cardiometabolic Risk And Autonomic Function Alterations In Normal Weight Obesity

Abstract

Introduction: Normal weight obesity (NWO) is defined by the presence of normal body mass index (BMI) with high body fat percentage. In this setting, high body fat seems to affect even non-obese individuals, predicting cardiovascular risk. Hypothesis: High body fat percentage, in eutrophic individuals, affects anthropometry, hemodynamic, autonomic function and cardiometabolic risk. Methods: This cross-sectional study recruited workers of a public hospital from 2018 to 2020. Inclusion criteria: age ≥ 18 yr.; BMI: 18.5 to 24.9 Kg/m 2 . Exclusion criteria: pregnancy/lactating women; BMI < 18.5 Kg/m 2 or ≥ 25 Kg/m 2 . High body fat percentage was categorized, by sex and age, as: 20 to 39 years, >19.9% and >32.9%; 40 to 59 years, >21.9% and >33.9%; and 60 to 79 years, >24.9% and >35.9% for men and women, respectively. Blood assays: fasting glucose, lipid profile and C reactive protein; anthropometry: neck, waist and hip circumferences; bioimpedance: visceral fat area and body fat percentage; hemodynamic parameters: blood pressure and double product; autonomic function: orthostatic test (30:15 ratio), orthostatic hypotension test and heart rate variability (HRV): high and low frequency and sympathovagal index; cardiometabolic risk: body shape index, atherogenic dyslipidemia, atherogenic index, atherogenic index of plasma and Framingham score. Statistical analysis: Mann-Whitney and chi-squared test. P<0.05. Ethics: according to Helsinki declaration, revised in 2013. Results: A total of 52 from 241 volunteers were eutrophic: 23 were NWO, that exhibited higher visceral fat area, anthropometric measures, blood pressure and double product; and worse lipid profile, HRV frequency domain and cardiometabolic risk parameters compared to the 29 with normal body fat percentage (table 1) . Conclusions: NWO individuals have metabolic, hemodynamic, anthropometric and autonomic alterations that, associated with new indexes related to atherogenesis, confirm the early cardiometabolic risk of this profile.