Abstract P016: Association Between Life’S Simple 7 Score And Cognitive Status In Older Adults With Atrial Fibrillation

Abstract

Introduction: The American Heart Association’s Life’s Simple 7 (LS7) score is a well-validated metric of cardiovascular health shown to be associated with cognitive status in numerous cardiac cohorts. However, little is known regarding this relationship in older adults with atrial fibrillation (AF). We aim to characterize LS7 scores in this population and examine its relationship with cognitive status. Hypothesis: We hypothesize that LS7 score is associated with cognitive status in older adults with AF. Methods: The Systematic Assessment of Geriatric Elements in AF (SAGE-AF) study is a longitudinal cohort of patients over 65 years of age who are diagnosed with AF from Massachusetts and Georgia. The LS7 components are collected through self-reported data from the baseline visit as well as medical records. Cognitive status is operationalized using the Montreal Cognitive Assessment (MoCA). Descriptive statistics were calculated and univariate logistic regression using tertiles of LS7 as exposure was used to assess the relationship between LS7 score and cognitive status. Results: A total of 1241 participants were included in study sample. Average age of the population was 76, 49% were female, and most of the sample were White (89%). Mean LS7 score was 7.92 (SD 2.05), and the tertile thresholds were 0-6, 7-9, and 10-14 (n = 302, 671, 268). Those in the lowest and middle tertiles of LS7 score were more likely than those in the highest to be cognitively impaired (lowest - OR 1.86, 95% CI 1.33 - 2.61; middle - OR 1.52, 95% CI 1.14 - 2.03) Conclusions: Most older adults with AF had LS7 scores of between 7-9 out of 14, and those with more favorable cardiovascular health were less likely to be cognitively impaired.