Abstract
Abstract The myc is a proto-oncogene that regulates the cellular process like cell growth, proliferation, metabolism, apoptosis and malignancy pathologies. myc deregulation occurs in several cancers and plays a significant role in disease development, metastatic potential, and therapeutic resistance. Drug targeting myc in cancer remains highly desirable with substantial challenges, delaying the direct myc targeted drugs’s development. These drugs target the myc transcriptions deregulations in tumours cell by compound inhibiting the inducing of epigenetic silencing or regulation of G-quadruplex structures within the myc promoter. Proteins involved in myc's post-translational modulation have been identified as significant surrogate targets for lowering myc activity downstream of aberrant cell stimulatory signals. Citation Format: Saeed Kabrah. myc Gene and cancer variant analysis and network interaction: An in-silico analysis [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2021 Oct 7-10. Philadelphia (PA): AACR; Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P008.
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