Abstract P-280: CONTINUOUS RENAL REPLACEMENT THERAPY IN CHILDREN LESS THAN OR EQUAL TO 12 MONTHS OLD: JAPANESE SINGLE CENTER EXPERIENCE

Abstract

Aims & Objectives: The outcomes in children less than equal to 12 months old who require continuous renal replacement therapy: CRRT were poor. The widely used CRRT machines on PICUs were originally developed for adults. The aim of this study was to review the data from patients less than or equal to 12 months old who required CRRT in our center, and to compare the results with the current literature. Methods Single center, retrospective study of patients admitted to the PICU at National Center for Child Health and Development from 1st January 2009 to 31st December 2016. CRRT was carried out with TR55X or TR525 (Ube Junken, Japan) in which blood flow rate can be started at 1ml/min. Clinical data from these children were analyzed, and the differences between survivors and non-survivors were evaluated. Results In total, 95 CRRT cases were included in the study. Indications of CRRT were hepatic failure 47, sepsis 20, Inborn error of metabolism 16, primary renal disease 7, others 5 (overdose 4, fluid overload 1). Mean pediatric index of mortality-2: PIM-2 was 19.2 (median 10.7, Interquartile range: IQR 5.0–25.3)%, and median pediatric logistic organ dysfunction was 13 (IQR 3–22). Survival rate of our cohort at ICU discharge was 91.6% (87/95). Survivors were more likely to have lower percent fluid overload at CRRT initiation. Conclusions We have shown that CRRT can be performed with pretty good outcomes in children less than equal to 12 months old compared to past reports.