Abstract P-167: CLINICAL ANALYSIS OF HUMAN BOCAVIRUS INFECTION IN CHILDREN WITH SEVERE LOWER RESPIRATORY TRACT INFECTION

Abstract

Aims & Objectives: To explore the clinical characteristics of human bocavirus (HBoV) infection in the children with severe lower respiratory tract infection. Methods The clinical data of the hospitalized children with sputum HBoV-positive from September 1st, 2016 to March 31, 2017 at the pediatric intensive care unit of Children’s Hospital Affiliated to Capital Institute of Pediatrics was analyzed retrospectively. Results A total of 17 children were included in the study. The ratio of male to female was 15:2. The diagnostic age was 4 months to 4 years and 10 months old. 82.4% of the patients were infants below 2 years old. Autumn and winter were high-occurrence seasons. The main clinical manifestations were respiratory system involvement, including fever, cough, wheezing, and dyspnea. The main abnormal chest radiological findings were patchy shadows and consolidation. Type I respiratory failure occurred in 11 cases (64.7%), while type II respiratory failure occurred in 6 cases (35.3%). All of the patients need respiratory support with mechanical ventilation. Among them, 6 patients (35.3%) were treated by non-invasive ventilation, and 11 patients (64.7%) were treated by invasive ventilation. Other organ dysfunction was mild. The length of hospital stay ranged from 3 days to 13 days. The cure rate was 100%. Conclusions HBoV infection in the children with severe lower respiratory tract infection was common in infants under 2 years old, with acute onset and rapid recovery. The obvious clinical symptoms were fever, cough, wheezing and dyspnea. Although respiratory failure was common, other organ dysfunction was mild, which led to a good prognosis.