Abstract P-106: PLASMAPHERESIS IN COLCHICINE POISONING: CAN IT BE A TREATMENT OPTION? CASE REPORTS

Abstract

Aims & Objectives: Colchicine toxicity is uncommon and it is associated with high morbidity and mortality. Colchicine is known to have a narrow therapeutic index and the exact toxic dose seems to be unknown. In this case report, we would like to emphasize that plasmapheresis therapy is effective in treating a patient receiving high-dose colchicine for suicide. Methods Case: The patient was 16 years old, 43 kg, girl. Colchicine (0,5 mg) received 24 tablets 12 hours before admission. Her complained of severe diarrhea and nausea. Physical examination and laboratory parameters were normal. The patient was taken from this drug at a high dose of 12 mg and severe gastrointestinal system complaints began at 12 hours. Results The patient was given active charcoal 10 times in repeated doses for 6 hours. At the 16th hour and 40th hour of the patient, one and a half plasma volumes were administered with 2 plasmapheresis treatments each for 6 hours. No complications were observed during and after the procedure. At 72 hours, the platelet count decreased to 100000/μL and AST-ALT values increased by 3 times as normal, then turn to normal within 3 days. The patient was discharged on the 10th day of admission, had no abnormality in the control on the 20th day. Conclusions In literature, plasmapheresis has not been shown as an effective treatment option in colchicine intoxication. It is emphasized that this treatment option can be used safely in pediatric patients in patients receiving high dose colchicine and in cases where FAB antibodies are not available.