Abstract of Invited Speaker : An Overview of Ganoderma lingzhi Constituents on α-Glucosidase and Aldose Reductase Inhibitory Activity

Abstract

Ganoderma lingzhi is the medicinal woody mushroom which have been known to have hundreds bioactive compounds. The lanostane-type triterpenoids with carboxyl group in the side chain or known as ganoderma acids were isolated from the fruiting body of G. lingzhi . Some of these compounds were established as active inhibitors of α- glucosidase and human recombinant aldose reductase in vitro . The research objective is to enlighten the role of structural requirement of ganoderma acids both for α-glucosidase and aldose reductase inhibition. Comparing the inhibitory activity of these two enzymes, the structure–activity studies of ganoderma acids showed that the hydroxyl substituent at C-11 and the carboxylic group in the side chain are an important feature both for the recognition of α-glucosidase and human recombinant aldose reductase inhibitory activity. Furthermore, the double- bond moiety at C-20 and C-22 in the side chain and the hydroxyl substituent at C-3 of ganoderma acids enlarge the inhibitory activity of both enzymes. These outcomes offer an approach which to regard as the structural requirements of lanostane type triterpenoids acids from G. lingzhi . A consideration of these requirements is essential in order to develop a new type for substances that can be improved to prevent the diabetic complications