Abstract No. 685 In vitro bovine liver experiment of cisplatin-infused and normal saline-infused radiofrequency ablation with an internally cooled perfusion electrode

Abstract

Cisplatin is an effective agent for the treatment of many malignant tumors and is mainly administered through intraarterial or intravenous route. Internally cooled perfusion electrode allows interstitial solution infusion during radiofrequency ablation (RFA). Purpose of this study was to evaluate the influence of cisplatin-infused and normal saline-infused radiofrequency ablation with internally cooled perfusion electrode on the size of ablated lesions. Using a 200W generator, thirty ablation zones were divided into three groups of 10 each and created as follows: group A, RFA alone with 16 gauge monopolar internally cooled electrode; group B, cisplatin-infused RFA with 16 gauge internally cooled perfusion electrode; and group C, normal saline-infused RFA with 16 gauge internally cooled perfusion electrode. RF was applied to the explanted bovine liver for 12 minutes. During RFA, cisplatin and normal saline were injected into tissue at a rate of 0.5 mL/min through the internally cooled perfusion electrode by injection pump. Dimensions of the ablation zone and technical parameters were compared between the three groups. In the cisplatin-infused RFA group, the ablation zone size was significantly larger than that of the RFA alone group but significantly smaller than normal saline-infused RFA group. The width of longitudinal section and volume were 3.39 ± 0.22 cm2 and 26.55 ± 4.62 cm3 in RFA alone group, 3.88 ± 0.32 cm2 and 36.45 ± 5.46 cm3 in cisplatin-infused RFA group, and 4.52 ± 0.50 cm2 and 49.44 ± 7.55 cm3 in normal saline-infused RFA group, respectively (p<0.05 between any two groups). The mean impedance in group A, B, and C were 60.0 ± 7.2, 50.3 ± 2.5, and 40.3 ± 4.0 Ω, respectively (p<0.05 between any two groups). Cisplatin-infused RFA with internally cooled perfusion electrode created the larger size of ablation zone than that of monopolar RFA with an internally cooled electrode, but created the smaller size of ablation zone than that of normal saline-infused RFA.