Abstract No. 590 Contralateral lobe hypertrophy after selective Y90 radioembolization/Y90 segmentectomy

Abstract

To retrospectively analyze the extent of left liver lobe hypertrophy after selective Y90 radioembolization of a single right lobe hepatocellular carcinoma (HCC) A retrospective review was performed of all patients that underwent selective Y90 radioembolization/Y90 segmentectomy for right lobe HCC from November 2017- June 2020 at our institution. Pre- and post-treatment contralateral liver lobe volumes were calculated using manual volumetry utilizing the MIM software (Cleveland, OH). Percent hypertrophy of the contralateral lobe was obtained by calculating the ratios of post- to pre-treatment lobe volumes. 29 patients underwent Y90 segmentectomy for solitary right liver lobe HCC over the study period. Mean age of patients was 69.2 (53–86) years with 21 males and 8 females. All 30 patients had underlying cirrhosis. Mean imaging follow up was 14 [4–36] weeks. Left liver lobe hypertrophy was noted in 26 of 29 patients that underwent Y90 segmentectomy. The mean left liver lobe hypertrophy range was 17% (-13% to 55%). Y90 radiation segmentectomy appears to lead to substantial hypertrophy of the contralateral liver lobe. Future larger scale studies may be useful in examining the role of segmental Y90 radioembolization without Y90 radiation lobectomy in causing contralateral lobe hypertrophy.