Abstract No. 57: New coil evaluation in animal model multiorgan embolization

Abstract

Present a new coil characteristics and post embolization angiographic and pathologic findings in animal model. Nine swines were used for embolization of the left superior gluteal, hepatic and renal arteries with 3 and 5-Fr catheters. Different animals had immediate, 30 and 60 days angiographic and pathological evaluations. Hydrogel characteristics: free delivery (pushable/injectable), sizes of 0.018 and 0.035”, 2, 5 and 10 cm in length and 3- 8 mm in diameter. The hydrophilic polymers filaments are three-dimensional networks that swell in the presence of fluids and shrinks in the absence of it. The liquid component within the polymer allows for the free diffusion of oxygen, nutrients, and other molecules, whereas the polymer network provides a structural framework, making hydrogels biocompatible. It has water content of 70% (?) and swell up to 10 (?) times in weight. The poly (ether) makes up the bulk of the network while acrylic acid is used to impart expansion and control in the rate of expansion. Barium sulfate is added to opacify the hydrogel filaments. At 30 and 60 days follow-ups, angiographies showed persistent occlusion of the all embolized vessels and remarkable renal artery collateral circulation. Histology showed atrophic kidney, minimal hepatic and muscular tissue changes, complete thrombosis of the embolized vessels and minimal inflammatory response. One swine died due to renal dysfunction, no other clinical complications were observed. All the embolizations with the new coil were safe and effective in short and long term, with minimal inflammatory response.