Abstract
To establish gastric cancer in rabbits by injecting VX2 tumor pieces through left gastric artery catheterization. VX2 tumor pieces of size 0.5 × 0.5 mm were implanted into the left gastric artery under the guidance of the digital subtraction angiography (DSA) in 12 New Zealand rabbits. One week after the implantation, DSA and air barium double contrast radiography were performed to evaluate the growth of the tumors. Three rabbits were then sacrificed for histopathological analysis of the tumors immediately and survival time was observed in the other nine rabbits. The left gastric artery catheterization was successfully achieved in all rabbits. All animals survived one week after the implantation. Gastric tumors were demonstrated with DSA and the air barium double contrast radiography. The masses, ulcers and mucous membrane edema could be found in the stomachs of the three rabbits, one week after the implantation of VX2 tumor pieces. Gastric tumors with remarkable perforations were confirmed in the other nine animals. The median survival time of the VX2 gastric cancer rabbits was 12 days in the current study. The implantation of VX2 tumor pieces into the left gastric artery is feasible to establish gastric cancer in rabbits, a promising animal model for the researchers on interventional oncology, radiology, and surgery.
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