Abstract No. 524 Transcatheter arterial embolization and magnetic ablation in VX2 Liver tumors by using high-performance poly(lactic-co-glycolic acid)-magnetic microspheres

Abstract

To evaluate the feasibility and therapeutic effects of combined embolization with magnetic hyperthermia in VX2 liver cancer model. Poly(lactic-co-glycolic acid) (PLGA)-magnetic microspheres (MMs) with100 μm were prepared via rapid membrane emulsification platform. In total, 45 VX2 liver-tumor-bearing rabbits were randomly assigned to five groups (n = 9/group) and received embolization with PLGA magnetic microspheres (Group 1), embolization plus alternating magnetic field (Group 2), embolization plus alternating magnetic field for temperature measurements (Group 3), alternating magnetic field (Group 4), or saline (Group 5) day 14 after tumor implantation. Tumor Response was measured by CE-CT. Hepatic toxicity, VEGF expression and survival were detected. Experimental results demonstrated that while exposed to alternating magnetic field after TAE, the tumor edge could be heated up by more than 15°C in vivo, whereas only a negligible increase of temperature was observed in the normal hepatic parenchyma nearby. Hepatotoxicity occurred but were transient. Tumor growth was delayed,VEGF were significantly inhibited and survival was prolonged in rabbits received a combination of embolization plus alternating magnetic field. PLGA magnetic microspheres-based arterial hyperthermia is a safe and effective treatment.