Abstract No. 397 Adrenal vein sampling with slow infusion of Cosyntropin for identifying surgically curable cases

Abstract

Adrenal vein sampling (AVS) for primary hyperaldosteronism aims to lateralize aldosterone production for potential cure by surgical resection. ACTH stimulation with Cosyntropin can improve selectivity; however, there are reports that it underestimates surgically remediable cases by nearly 25% (Yozamp et al., 2021). Conventional protocols stimulate the adrenal glands with a Cosyntropin bolus prior to AVS; however, slow infusion without a bolus is another option. This study investigates AVS outcomes after slow Cosyntropin infusion of an intermediate dose as it relates to selectivity, lateralization, surgical pathology, and clinical hypertension.